Malaysian Journal of Biochemistry
& Molecular Biology
(E-ISSN: 2600-9005)
The Official Publication of the Malaysian Society for Biochemistry & Molecular Biology (MSBMB)
Indexed by SCOPUS and Malaysian Citation Index (MYCITE)
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April 2026
Malay. J. Biochem. Mol. Biol. (2026) 29 (1)
Page range 1-130
Regular Article
DOI:
Page 104-118
Gusti Ayu Dewi Lestari, Angela Meichi Patriadila Puspita, I Putu Aditya Vidyananda, Ni Ketut Esati, Ni Luh Putu Kris Monika Yanti, Aliya Nur Hasanah and Balaprasad Ankamwar
IMPACT OF CANANG WASTE-DERIVED NANOSILVER SUNSCREEN ON TNF-α AND IL-1β EXPRESSION IN UVB-EXPOSED MICE SKIN
Abstract
This study aimed to test the sunscreen activity of green-synthesized nanosilver mediated by canang waste. This study was designed in several stages: green synthesis of nanosilver from canang waste and its characterisation; formulation of a green-synthesized nanosilver sunscreen cream; in vivo testing of the nanosunscreen and the inflammatory markers TNF-α and IL-1β. This study obtained results, namely the formation of green-synthesized nanosilver with a maximum wavelength of 410 nm, spherical shape, size of 63.94 nm, polydispersity index of 0.3026, zeta potential of -30.81 mV, and containing several functional groups that stabilise its formation. Furthermore, a green- synthesized nanosilver cream preparation was obtained that met the physical quality parameters of the cream. An in vivo study shows that the results of the positive control group were significantly different from those of the negative control group (p < 0.05). In contrast, the positive control group did not differ significantly from the F2 and F3 groups containing the active ingredient, green- synthesized nanosilver. This proves that green synthesised-nanosilver can play a role in protecting the skin from UV rays. In expression of TNF-α and IL-1β, green- synthesized nanosilver was able to suppress the inflammatory process/erythema caused by UVB rays with p-value > 0.05, which indicated that the results were not significantly different between normal skin without treatment and the F3 group, which used 3% green-synthesized nanosilver.